Abstract:
Sickle Cell Disease is a genetic mutation in the haemoglobin gene which results in chronic hemolytic anaemia
and progressive damage to multiple organs that affect the immune system. However, little is known about how
this disease affects the adaptive immune response. This paper offers a summary of sickle cell disease from an
immunological standpoint. PRISMA-compliant electronic articles from Google Scholar, PubMed, Research Gate,
and Scopus were obtained by searching for terms like “immunological cells,” “red blood cells,” and “white blood
cells.” The findings of this study indicate that persons with sickle cell anaemia are more prone to infection and
inflammation due to the damage that might occur to their irregularly shaped red blood cells. Bone marrow and
stem cell transplantation have been shown to be among the best strategies to treat sickle cell disease holisti-
cally. While new medications are being created, more research must be done to understand how the immune
system, in particular the adaptive immune system to rectify this aberration.
